Cisplatin history
WebSep 15, 2024 · Cisplatin has activity against multiple tumor types and was approved for use by the United States in 1978. Current indications include testicular, ovarian and bladder … WebSep 24, 2024 · Cisplatin (CDDP) is the drug of choice against different types of cancer. However, tumor cells can acquire resistance to the damage caused by cisplatin, generating genetic and epigenetic changes that lead to the generation of resistance and the activation of intrinsic resistance mechanisms in cancer cells. Among them, we can find mutations, …
Cisplatin history
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WebAbstract. Cisplatin is a triumph which elucidates many aspects of clinical cancer research in general and drug development research in particular. As is well known cisplatin was discovered initially by a brilliantly intuitive serendipitous observation by Dr. Barrett Rosenberg. (1) The critical step in bringing the drug to clinical trial was the ... WebApr 15, 2024 · Based on medical history and clinical manifestations, the solid space-occupying lesion in the left atrium was suspected to be cardiac metastases from bladder cancer despite treatment with pirarubicin, gemcitabine and cisplatin. On chest CT, enlarged lymph nodes beneath the right hilar and mediastinal carina were observed, which …
WebCisplatin is contraindicated in patients with a history of allergic reactions to cisplatin or other platinum-containing compounds. WARNINGS . Cisplatin produces cumulative nephrotoxicity which is potentiated by aminoglycoside antibiotics. The serum creatinine, blood urea nitrogen (BUN), creatinine clearance, and magnesium, sodium, WebFollowing extensive research and development during the mid-70s, cisplatin was approved by the U.S. Food and Drug Administration (FDA) as an anticancer drug in 1978 and was …
WebApr 25, 2024 · The actual dose of cisplatin administered to each of the 87 patients was extracted from the electronic medical record system of Kurume University Hospital. Dividing it by the body surface area of the patient, the dose of cisplatin in mg per body surface area (mg/m 2) of each patient was established. Data WebThe Italian chemist Michele Peyrone first reported cisplatin synthesis in 1844 (ref. 3), but the biological activity of cisplatin was shown for the first time in 1965, when Barnett Rosenberg and ...
WebNov 21, 2024 · The actual chemical compound of cisplatin is cis - [Pt (NH3)2Cl2] and was identified by Michele Peyrone in 1845, known at that time as Peyrone's salt [1]. However …
WebOccasionally reactions secondary to cisplatin therapy have been reported. Patients receiving cisplatin should be observed carefully for possible anaphylactic-like reactions and the necessary equipment and medication should be readily available to treat such reactions. Patients with a family history of atopy are at particular risk. dynamic instability is a:WebJul 18, 2024 · Cisplatin Brand name: Platinol-AQ Drug class: Antineoplastic Agents - Platinum-containing Agents VA class: AN900 Chemical name: (SP-4-2)-Diamminedichloroplatinum Molecular formula: Cl 2 H 6 N 2 Pt CAS number: 15663-27-1 Medically reviewed by Drugs.com on Jul 18, 2024. Written by ASHP. Introduction Uses … crystal\u0027s geWebSep 1, 2024 · Cisplatin for injection has been administered at 20 mg/m 2 intravenously daily for 5 days per cycle. Other doses and combination regimens have been used. … dynamic insurance services glassdoorWebFeb 16, 2024 · Common side effects of cisplatin may include: hearing problems; kidney problems; numbness or tingling; nausea, vomiting; or. bone marrow suppression. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. dynamic insurance brokers adelaideWebNov 21, 2024 · However, cisplatin is also used to fight brain tumors. The actual chemical compound of cisplatin is cis - [Pt (NH3)2Cl2] and was identified by Michele Peyrone in 1845, known at that time as ... dynamic insurance services jobscrystal\\u0027s ghWebFeb 1, 2024 · Descriptions. Cisplatin injection is used to treat advanced cancer of the bladder, ovaries, or testicles. Cisplatin is an antineoplastic agent (cancer medicine). It interferes with the growth of cancer cells, which are eventually destroyed by the body. This medicine is to be given only by or under the direct supervision of a doctor. crystal\u0027s gi