WebDaptomycin is a lipopeptide antibacterial with a spectrum of activity similar to vancomycin but its efficacy against enterococci has not been established. It needs to be given with other antibacterials for mixed infections involving Gram-negative bacteria and some anaerobes. Indications and dose WebNo patient (0%) developed muscle pain or discomfort and none developed markedly elevated CK levels. The incidence of asymptomatic elevations of CK in these simvastatin or rosuvastatin plus daptomycin recipients (9%) was statistically indistinguishable from the incidence of CK elevations found in a cohort of 105 inpatients who received ...
The impact of daptomycin therapeutic drug monitoring on clinical ...
Webfunction tests, elevated creatinine phosphokinase (CPK), urinary tract infections hypotension, and dyspnea. (6.1) • Pediatric cSSSI Patients: The most common adverse … WebDaptomycin is reported to cause an elevation in creatine kinase levels, although frank rhabdomyolysis is rare. An even more infrequent occurrence is the simultaneous … citroen dispatch front bulkhead racking
Teva Strengthens Injectables Portfolio with the Launch of an …
WebNov 23, 2024 · Daptomycin Dosage Medically reviewed by Drugs.com. Last updated on Nov 23, 2024. Applies to the following strengths: 500 mg; 350 mg Usual Adult Dose for: Skin and Structure Infection Bacteremia Endocarditis Usual Pediatric Dose for: Skin and Structure Infection Bacteremia Additional dosage information: Renal Dose Adjustments … WebFeb 1, 2024 · The key toxicity associated with daptomycin is CPK elevation, with risk being increased with high-dose, off-label prescribing. Daptomycin trough concentrations ≥19.5 mg/L or ≥24.3 mg/L have been associated with increased probability of CPK elevation [14, 15]. Variation was also observed in the target concentration for efficacy. WebSep 14, 2024 · Management of such CPK elevations has traditionally been discontinuation of the offending agent, with many studies showing a resolution of a normal CPK level within 1 week of discontinuation and no long term adverse effects. Nevertheless, the question remains if daptomycin can be successfully restarted in such patients. dick payne us bank