WebDec 11, 2024 · The key difference between intrinsic and extrinsic pathway of apoptosis is that the intrinsic pathway of apoptosis begins when an injury occurs within the cell and the resultant stress activates the apoptosis, while the extrinsic pathway of apoptosis begins when conditions in the extracellular environment determine that the cell must die and … WebA. Excellent question!! And one that a lot of students have asked in class. “Intrinsic” sounds like the important pathway that happens in the body, and “extrinsic” sounds like one that might happen in the lab, or outside the body. But that’s not at all what the names mean! The two pathways were named that way because of the way ...
Functional difference between intrinsic and extrinsic ... - PubMed
WebAug 7, 2006 · Thus, defects in the intrinsic or extrinsic pathway may promote tumor progression and therapy resistance. Accordingly, targeting defective apoptosis programs … WebQ. Compare and contrast intrinsic and extrinsic pathways involved in apoptosis and provide examples of key regulators of these specific pathways that show abnormal expression/ activity in cancer. Cancer is a multifactorial disease, one factor may involve the lack of appropriate cell death. In the adult multicellular organism, there are very ... literacy partners foundation
The concept of intrinsic versus extrinsic apoptosis - PubMed
WebAug 7, 2006 · Killing of tumor cells by most anticancer strategies currently used in clinical oncology, for example, chemotherapy, gamma-irradiation, suicide gene therapy or … WebAug 7, 2006 · Understanding the molecular events that regulate apoptosis in response to anticancer chemotherapy, and how cancer cells evade apoptotic death, provides novel opportunities for a more rational approach to develop molecular-targeted therapies for combating cancer. Publication types Research Support, Non-U.S. Gov't Review MeSH … WebThe intrinsic pathway is activated by factors in the blood, while extrinsic is activated by tissue factor. Both pathways result in activation of factor X leading into the common … importance of 25th amendment