WebApr 8, 2024 · iRGD (structure in Fig. 3) is a disulfide based cyclic RGD (CRGDKGPDC), which can enhance the penetration of the drugs in a neuropilin dependent manner. Considering the present scenario, iRGD has come up as a ray of hope for the management of cancer. WebDec 3, 2024 · Theoretically, after collecting exosomes from HEK293T cells that express siRNA-KRAS/iRGD plasmid and injecting the redesigned exosomes into tumor-bearing mice, the iRGD tag that was engineered to be expressed on the exosomal membrane would guide the exosomes to tumor cells to release KRAS siRNA.
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