Lamp2a knockout mouse
Webb7 juli 2024 · The role of chaperone-mediated autophagy (CMA) in cancer initiation and progression is not well understood due to the lack of a loss-of-function cancer models of LAMP2A, the key regulator of this process. Here, by generating an isoform-specific knockout of LAMP2A, we show that CMA deficiency promotes proliferation and tumor … Webb31 jan. 2015 · To elucidate the neuronal function of LAMP-2 we analyzed knockout mice for neuropathological changes, MA and steady-state levels of CMA substrates. The …
Lamp2a knockout mouse
Did you know?
WebbKacal M, Zhang B, Hao Y, Norberg E, Vakifahmetoglu-Norberg H (2024) Quantitative proteomic analysis of temporal lysosomal proteome and the impact of the KFERQ-like motif and LAMP2A in lysosomal targeting. Autophagy 26:1–10 Wang H, La Russa M, Qi LS (2016) CRISPR Cas9 in genome editing and beyond. Annu Rev Biochem 85(1):227–264 WebbImmunohistochemical analysis of paraffin-embedded Mouse liver labeling LAMP2A with unpurified ab125068 at 1/500 dilution, followed by Goat Anti-Rabbit IgG H&L (HRP) at …
Webb14 apr. 2024 · Cyagen의 AI Knock-Out Mouse Model eBank에서는 16,000 strains 이상의 KO/cKO 마우스 모델을 보유하고 있으며, 연구자들이 가장 짧은 시간 내에 최고의 가성비를 가진 실험용 마우스를 얻을 수 있도록 최대 2주 안에 Live 마우스를 제공합니다. 우리의 AI Knock-Out Mouse Model eBank는 ... Webb10 juni 2024 · Similarly, the loss of chaperone-mediated autophagy through Lamp2A knockout (Lamp2A flox/flox; Alb-Cre) also promotes the development of hepatocellular adenomas with increasing age []. Yet whilst the loss of autophagic activity can drive the initial formation of tumorigenesis, this is limited to benign adenomas, and no malignant …
WebbAnti-LAMP2A antibody [EPR4207 (2)] - Lysosome Marker (ab125068) Research with confidence – consistent and reproducible results with every batch. Long-term and … Webb3 sep. 2024 · Anti-LAMP2A antibody catalog : ab18528 quantity : 100 µg clonality : polyclonal host : domestic rabbit conjugate : nonconjugated reactivity : human, mouse, rat application : western blot, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, western blot knockout validation
http://www.informatics.jax.org/marker/MGI:96748
Webb兔多克隆抗体to LAMP2A - Lysosome Marker 宿主 Rabbit 经测试应用 适用于: WB, ICC/IF, IHC-P more details 种属反应性 与反应: Mouse, Human 预测可用于: Dog, Monkey, Chinese hamster 免疫原 Synthetic peptide corresponding to Human LAMP2A aa 350 to the C-terminus (C terminal) conjugated to keyhole limpet haemocyanin. LAMP2 has 3 … riverside march air force baseWebbShown are the major pathways targeted by the compounds and genetic manipulations (depletion by siRNA, deletion by knockout ... extended to whole organisms, for example, by feeding mice with 15 N labeled algae or a 13 C 6 ... deprivation and exquisitely dependent on the lysosomal membrane protein LAMP2A (Kaushik and Cuervo, 2024. riverside marco island rentalsWebbLAMP2A knockout results in a decreased CMA activity, which leads to increased PLIN2 expression, decreased lipid oxidation and subsequent ... Interestingly, SNX10 knockout mice exhibited significantly ameliorated ethanolinduced hepatic - steatosis and injury via inhibition of CTSA maturation, LAMA2A stabilization and, thus, CMA riverside maternity newport news va